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CRM Reference material is used by laboratories to control accuracy in studies such as device calibration, method validations, method comparisons, research and development processes. It is stable and sufficiently homogeneous. Certified reference material (CRM), on the other hand, is the materials offered for use with certificates of proven stability and homogeneity, which are used for the purposes of calibration, method development, reality check, adequacy determination and quality control. Certified reference materials used for the calibration of GC, GC-MS, HPLC, AAS, ICP, ICP-MS devices are used in many areas such as environment, food, mining, geology, medicine and biochemistry.

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